Shop by goal
Popular compounds
Research resources
Recently viewed
PNC-27 peptide: Metabolic / Longevity research guide
In short: PNC-27 is a 32-residue chimeric peptide: p53 residues 12-26, which form an HDM-2 binding domain, joined to a 17-residue membrane-residency leader. Studied in cell lines for membrane pore formation. It is studied in preclinical (cell and animal) research and is supplied strictly for laboratory use, not for human or clinical use.
Not medical advice. PNC-27 is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
PNC-27 at a glance
What to know first
Details and limits sit in the sections below. Research use only. No unsupported scientific claims are added here.
What PNC-27 is
PNC-27 is a 32-residue chimeric peptide: a 15-residue p53 segment that binds HDM-2, fused to a 17-residue penetratin-type leader.
One-paragraph overview from our research datasheet. Still scientific, but faster to read than the full mechanism list below.
PNC-27 is a 32-residue chimeric peptide: p53 residues 12-26, which form an HDM-2 binding domain, joined to a 17-residue membrane-residency leader. Studied in cell lines for membrane pore formation.
Research contexts
Peer-reviewed papers discuss PNC-27 in specific lab settings. The points below reflect research questions, not health claims.
Research vs. personal use: Literature describes experiments in cells and animals. That is distinct from real-world use. Our products are for laboratory research only.
Typical study contexts
Why Metabolic / Longevity research matters
Researchers study these compounds for mitochondrial function and cellular energy stress. Ageing and metabolic disease models are common.
Mechanisms (technical review)
Our datasheet lists mechanistic themes from preclinical work. These are research endpoints, not health claims.
Lab handling & preparation
Common Questions People Are Asking
What is PNC-27?
PNC-27 is a 32-residue chimeric peptide made of p53 residues 12-26, an HDM-2 binding domain, followed by a 17-residue membrane-residency leader. It is supplied here as laboratory research material only.
What does the published research measure?
The cited papers examined the peptide in cultured cell lines, by electron microscopy, by NMR and by modelling. They reported membrane pores in the cancer cell lines tested and none in the untransformed cells used as controls. They are laboratory findings and not claims about the supplied material.
Are there human data?
No controlled human data are cited on this page. The literature referenced here is in-vitro and structural work, so it does not establish safety, effect or intended use in people.
Why is there no molecular weight or formula listed?
None of the sources opened for this page states one, so the page omits them rather than quote an unverified number.
Is there a Certificate of Analysis for PNC-27?
Not yet. No independent analytical report has been published for this material, so no purity figure is quoted.
Is PNC-27 for human use?
No. It is sold for in-vitro and preclinical research only, is not a medicine, and is not for human or veterinary use.
Is this page medical advice? Can I use PNC-27 for my health?
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Where do I find PNC-27 specs, purity certificates and pricing?
Open the shop listing via “View product details.” There you will see concentration, purity grade, and available SKUs with current pricing. No current Certificate of Analysis is published for PNC-27 yet; published certificates are listed at /coa.
Related peptide guides
Other compounds researchers often read about alongside PNC-27.
Scientific sources & further reading
Primary literature and registries for PNC-27, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
Ready to order? View full product specs
Access concentration, batch info, variants, and current pricing on our shop.
Also known as: PNC-27, p53 (12-26)-membrane residency peptide chimera, chimeric p53-penetratin peptide
PRECISION. PURITY. PERFORMANCE.
Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.
Shop
Research
Support
Ways to Pay
Shop by goal
Shop by compound
Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
All rights reserved. Copyright of New-U held with Hilxera Distribution Services LLC 2026.
Website & business operated by Hilxera Distribution Services LLC. Registered in Wyoming, ID: 2026-001928701.
Principal office: 1712 Pioneer Ave., Ste. 500, Cheyenne, WY 82001, USA
© 2026 New-U Research Compounds · new-u.io
[image: New-U Research Compounds on PepFinder, live PepFinder store rating]