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Vitamin B12
Vitamin B12 (cobalamin) as lyophilised research powder in 5 mg and 10 mg vials, sealed 10-vial packs. The organometallic cofactor of methionine synthase and methylmalonyl-CoA mutase.
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Vitamin B12
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Lab-direct quality — sealed 10-vial packs
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a sealed 10-vial research pack in the strength your research needs.
Scientific Research Context
What the published biochemistry of vitamin B12 examines. These are findings about the cofactor in the studies cited, not claims about the supplied material.
Cobalamin-dependent enzyme chemistry
A review describes vitamin B12 as a complex organometallic cofactor for three enzyme subfamilies: the adenosylcobalamin-dependent isomerases, the methylcobalamin-dependent methyltransferases and the dehalogenases. The cobalt-carbon bond breaks homolytically in the isomerases and heterolytically in the methyltransferases. [review, biochemistry]
Uptake, assimilation and delivery
Because the cofactor is so reactive and scarce, higher eukaryotes that use it evolved a system to take it up, convert it to its active forms and deliver it to the B12-dependent enzymes. A review covers the proteins involved and what is known about the intracellular route. [review, cell biology]
Removing the cyanide ligand
The trafficking chaperone MMACHC catalyses a reductive decyanation of cyanocobalamin, using electrons from NADPH through flavoprotein oxidoreductases, to give cob(II)alamin, a substrate for assimilation into methylcobalamin and 5'-deoxyadenosylcobalamin. [in vitro, enzymology]
Dealkylation with glutathione
MMACHC also removes the alkyl group from methylcobalamin and 5'-deoxyadenosylcobalamin using the thiolate of glutathione, with turnover numbers of 11.7 and 0.174 per hour respectively at 20 °C. [in vitro, enzymology]
Overview
In short: Vitamin B12 is a cobalt-containing organometallic cofactor, studied for the reactivity of its cobalt-carbon bond and for the cellular machinery that converts and delivers it to the two mammalian enzymes that depend on it.
Key research facts
These points summarise lab themes, not human outcomes.
The compound is a family rather than a single molecule: cyanocobalamin, hydroxocobalamin, methylcobalamin and adenosylcobalamin differ in the group bound to cobalt, and the cell converts the forms it takes up into the two active cofactors. That is why the chemical form matters in research, and why this page does not assume one. The supplier list names the material only as Vitamin B12, so no formula, molecular weight or purity is stated here.
Two enzymes are named in the cell-biology literature as the B12-dependent targets in mammals: methionine synthase and methylmalonyl-CoA mutase. The processing papers cited here show how a cyanocobalamin or an alkylcobalamin entering a cell is stripped of its ligand by MMACHC (reductively with NADPH-derived electrons for the cyanide, with glutathione for an alkyl group) before being rebuilt into the active cofactors.
This is a vitamin that is also sold as a medicine and as a supplement elsewhere; the material on this page is neither. It is supplied as a lyophilised powder for in-vitro and preclinical research, in 5 mg and 10 mg vials, and no analytical report for it has been published yet.
Mechanism in the Published Biochemistry
Cobalamin works by the chemistry of its cobalt-carbon bond, which supports methyl transfer in one enzyme and isomerisation in the other. Cells convert the forms they take up into the two active cofactors through a dedicated trafficking system.
Defects in MMACHC are described as the most common cause of inborn errors of B12 metabolism, and fibroblasts lacking it respond poorly to cyanocobalamin but show some correction with aquocobalamin, a form without the cyanide ligand. That observation is the practical reason the chemical form is a research variable. None of this describes the supplied material, whose form is not stated on the supplier list.
Common Questions People Are Asking
What is Vitamin B12?
Vitamin B12, or cobalamin, is a cobalt-containing organometallic cofactor. It is the cofactor for two mammalian enzymes named in the cell-biology literature, methionine synthase and methylmalonyl-CoA mutase. It is supplied here as a laboratory research powder only.
Which form of vitamin B12 is it?
The supplier list names the compound as Vitamin B12 and does not state whether it is cyanocobalamin, methylcobalamin, hydroxocobalamin or adenosylcobalamin. This page does not assume one, and quotes no formula or molecular weight, because they differ by form. The form will be stated if an analytical report is published.
Is this a supplement or a medicine?
No. Vitamin B12 preparations are sold as medicines and supplements in many places; the material on this page is laboratory research material, is not either of those, and is not for human or veterinary use.
Is there a Certificate of Analysis for Vitamin B12?
Not yet. No independent analytical report has been published for this material, so no purity figure is quoted. If one is published it will appear on this page and on our COA page.
What do the cited studies show?
They describe how cobalamin-dependent enzymes use the cobalt-carbon bond and how the MMACHC chaperone removes cyanide or an alkyl group from a cobalamin so that it can be rebuilt into the active cofactors. They are biochemical and cell-biology studies and none tests the supplied material.
Where can I buy Vitamin B12?
Right here - Vitamin B12 is supplied directly by New-U Research Compounds on this page, as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.
How much does Vitamin B12 cost?
Vitamin B12 pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, and shipping is free on orders over $350.
How do I buy Vitamin B12?
Add the Vitamin B12 pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step.
What payment methods can I use to buy Vitamin B12?
At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes - we ship worldwide in discreet, unmarked, tracked packaging; lyophilised peptides are stable through the tracked transit window. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.
Is it legal to buy Vitamin B12?
In the United States, Vitamin B12 is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.
Research use only - all claims made on this site are for testing and research use only.
Pharmacokinetics
Evidence Tier
Overall: Tier 3: Limited / anecdotal
The cited work is biochemistry and cell biology: reviews of the cofactor's enzymology and trafficking and two enzymology papers on MMACHC. None tests the supplied material, whose chemical form and purity are not documented. It is supplied as laboratory material only.
Databases & peer-reviewed sources
Last reviewed: 14 October 2026 · New-U Research Compounds
Key Characteristics
Specifications
About Vitamin B12 (Cobalamin): Research Material Guide
Vitamin B12 is better known as a nutrient than as a laboratory reagent, and that difference is the reason for the care taken on this page. The material here is laboratory research material in a lyophilised vial; it is not a medicine, a supplement or a food, and nothing here describes its effect in people or animals.
The published work worth reading for a bench scientist is the enzymology and cell biology of the cofactor: how the cobalt-carbon bond is used by the two B12-dependent enzymes, and how a cell converts the cyanocobalamin or alkylcobalamin it takes up into the active forms through the MMACHC chaperone. Those papers use defined cobalamin forms, which is why the form of the supplied material matters and why it is stated as unknown rather than guessed.
New-U Research Compounds supplies vitamin B12 in 5 mg and 10 mg vials as laboratory research material only. No analytical report has been published yet, so no purity, identity or form is claimed. Nothing on this page is medical advice.
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Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.
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Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
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[image: Vitamin B12 research vial — Metabolic compound supplied by New-U Research Compounds]
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